Nanomotor guided inside a living cell using a magnetic field

Nanomotor guided inside a living cell using a magnetic field

center_img More information: Malay Pal et al. Maneuverability of Magnetic Nanomotors Inside Living Cells, Advanced Materials (2018). DOI: 10.1002/adma.201800429AbstractSpatiotemporally controlled active manipulation of external micro‐/nanoprobes inside living cells can lead to development of innovative biomedical technologies and inspire fundamental studies of various biophysical phenomena. Examples include gene silencing applications, real‐time mechanical mapping of the intracellular environment, studying cellular response to local stress, and many more. Here, for the first time, cellular internalization and subsequent intracellular manipulation of a system of helical nanomotors driven by small rotating magnetic fields with no adverse effect on the cellular viability are demonstrated. This remote method of fuelling and guidance limits the effect of mechanical transduction to cells containing external probes, in contrast to ultrasonically or chemically powered techniques that perturb the entire experimental volume. The investigation comprises three cell types, containing both cancerous and noncancerous types, and is aimed toward analyzing and engineering the motion of helical propellers through the crowded intracellular space. The studies provide evidence for the strong anisotropy, heterogeneity, and spatiotemporal variability of the cellular interior, and confirm the suitability of helical magnetic nanoprobes as a promising tool for future cellular investigations and applications. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Engineers build world’s smallest, fastest nanomotor A team of researchers at the Indian Institute of Science in Bangalore has developed a type of nanomotor that can be guided inside of a living cell using an external magnetic field. In their paper published in the journal Advanced Materials, the group describes their nanomotor, how it works, and possible uses for it.last_img read more